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Boise State faces familiar foe at Wyoming, has ‘a lot of respect.’ What will weather do?Sira Thienou scores 16 points, No. 18 Ole Miss women coast to 89-24 win over Alabama State
State Rep. Tim Bonner, right, talks during the elected officials panel next to state Rep. Parke Wentling, center and state Sen. Michele Brooks, left, at the Mercer County Economic Summit on in July at Grove City College. HARRISBURG — Pennsylvania’s 2023-24 Legislative Session closed Dec. 1 and the next session, while officially underway, doesn’t fully begin until lawmakers are sworn into office Jan. 7. Looking back, members of the state House and Senate introduced 3,862 bills and 924 resolutions across the two-year session. There were 77 bills adopted into law in 2023 and 162 adopted in 2024. The combined total of 239 was far fewer than the previous six legislative sessions. There hasn’t been a lower total since 2009-10, when 226 bills advanced into law — the last time the Pennsylvania General Assembly had a partisan divide. Democrats controlled the House while Republicans led the Senate. Gov. Josh Shapiro, a Democrat, often cites the challenge of advancing legislation with a split government. That dynamic won’t change in 2025-26. Though there are 20 new members joining the legislature — 16 in the House, four in the Senate — the respective parties defended their majorities. Republicans have a 28-22 advantage in the Senate while Democrats maintained a 102-101 margin in the House. What follows is a look back at the outcome of legislation proposed last session by area lawmakers. State Sen. Michele Brooks speaks ahead of Gov. Josh Shapiro at The Hometown Pharmacy in July in New Castle. State Sen. Michele Brooks The start of the 2025-26 Legislative Session marks the midway point of Republican Sen. Michele Brooks’ third term in office. Her district, the 50th, includes Crawford, Mercer and most of Lawrence counties. Her current four-year term expires in 2026. In 2023-24, Brooks served as majority chair of the Senate Health and Human Services Committee and vice chair of the Finance Committee. Her other committee assignments were Agriculture and Rural Affairs, Communications and Technology, Education, Rules and Executive Nominations and Veterans Affairs and Emergency Preparedness. She sponsored 248 bills and resolutions last session including 60 bills and eight resolutions as a prime sponsor. The focus of the bills she introduced included eliminating inheritance taxes on siblings and other relatives, enacting consumer protections, the creation of a lost dog registry, extending the statute of limitations for the crime of drug delivery resulting in death, including sales taxes in advertised retail prices, addressing Lyme disease and expansive efforts to serve firefighters and EMS providers. Among the bevy of bills of which she was a prime sponsor, six became law and four others advanced to the House. The rest remained in the Senate. Motorcycles will be included in Pennsylvania’s Automobile Lemon Law after a Brooks bill became Act No. 151 of 2024, extending protections for manufacturer defects to a new class of vehicle. Senate Bill 500, a bipartisan bill known as Owen’s Law, became Act 32 of 2023. It allows for medical prescriptions through Medicaid of donor milk for children younger than 12 months. Brooks was successful in expanding Pennsylvania’s Safe Haven Law. Act 134 of 2024 adds urgent care centers to designated locations where parents may safely surrender newborns if they feel unfit to care for the child. She also secured an amendment to Pennsylvania’s Public School Code through Act 55 of 2024 that will allow professionals in skilled occupations to more easily receive state certification to teach at career and technical schools. Her bill was amended as part of budget negotiations to include numerous negotiated updates to the code beyond her original intent. Act 66 of 2023, born out of Brooks’ Senate Bill 941, eases eligibility and qualifications to become a drug treatment counselor and increases counselors’ patient caseload capacity during an opioid epidemic, defined as 1,000-plus opioid overdose deaths in three consecutive years. Pennsylvania schools must notify parents and guardians in writing whenever ticks are removed from students under Act 120 of 2024. Schools must provide information on the symptoms of Lyme disease and must preserve the tick for parents or guardians to either send into a state lab for analysis or allow the school to do so. Results are confidential. State Rep. Tim Bonner, R-Mercer/Butler, speaks inside the state Capitol in January 2023 announcing an appeal would be filed to the Pennsylvania Supreme Court concerning the delayed impeachment trial of Philadelphia District Attorney Larry Krasner. At left is fellow impeachment trial manager Rep. Craig Williams, R-Delaware. State Rep. Tim Bonner Rep. Tim Bonner, a Republican, returns to the Pennsylvania House in 2025-26 for his third full term. He won a special election in 2020 to represent the former 8th Legislative District and has since won three straight elections to the House. After redistricting took hold in 2022, he’s represented the redrawn 17th District, which includes parts of Mercer and Butler counties. He ran unopposed in 2024. In the now-expired 2023-24 session, Bonner was appointed to the committees on Ethics, Health, Judiciary and State Government. He also was the Republican chair of separate subcommittees on Health Facilities and Family Law. A legal battle that began in late 2022 carried almost throughout the entire two-year session, ending in September with the Pennsylvania Supreme Court ruling that impeachment proceedings against Philadelphia District Attorney Larry Krasner, a Democrat, couldn’t continue on procedural grounds. Bonner, a longtime prosecutor as an assistant district attorney in Mercer County, would have served in a prosecutorial role had the impeachment trial began. The 2023-24 session saw Bonner sponsor 33 bills or resolutions — 17 as a prime sponsor. All but one of those were introduced in the first half of the two-year session. One advanced out of the House, none became law. Members of the Pennsylvania House unanimously supported Bonner’s bill proposing that nursing homes be required to provide notice of legal representation whenever a facility resident applies for Medicaid. Once in the Senate, however, the bill didn’t receive consideration. He did see a provision from a bill proposal rolled into the commonwealth’s updated Wiretap Act last year, which now allows for the discreet recording of robocalls and telemarketers if there is a suspicion of fraud. Bonner, a member of the conservative Pennsylvania Freedom Caucus, joined a lawsuit filed by 24 state lawmakers against President Joe Biden, Gov. Josh Shapiro and the Pennsylvania Department of State concerning Pennsylvania’s shift to an opt-out automatic voter registration process at PennDOT driver's license and photo ID centers. The former opt-in process had been in place for 30 years before the change. The lawsuit was dismissed by a federal judge for lack of legal standing. Bonner was among 12 Republicans who voted in favor of a bill that proposed a medical debt relief program within the Department of Health. He opposed both budgets last session along with a proposed ban on “ghost guns.” He voted in favor of a bill seeking to increase transparency on campaign contributions by tax-exempt organizations and he voted along with 31 other House Republicans in support of the proposed Marriage Equality Act. State Rep. Parke Wentling, R-7th District, Hempfield Township, chats with Peggy Mazyck, retiring president and chief executive officer of the Mercer County Tourist Promotion Agency, at her retirement party in September at the Buhl Mansion Guest House and Spa on Sharon. State Rep. Parke Wentling Rep. Parke Wentling will serve his sixth term in the Pennsylvania House during the 2025-26 Legislative Session. Wentling, a Republican, represents western Mercer County, which makes up the 7th Legislative District. He was re-elected after running unopposed in the primary and general elections in 2024. During the 2023-24 session, Wentling’s committee assignments were Environmental Resources and Energy, Games and Fisheries, for which he served as Republican vice chair, Local Government, and Tourism & Economic & Recreational Development. He also served as Republican chair of the Subcommittee on Townships. Wentling sponsored 24 bills and resolutions last session, five as the primary sponsor and all introduced in 2023. One advanced to the state Senate, none made it into law. His legislation included a two-bill package with the support of House Republicans that sought to consolidate workforce development programs. Another proposed to expand eligibility for low-interest loans and lines of credit through the Pennsylvania Industrial Development Authority. A resolution introduced by Wentling sought to urge U.S. Congress to eliminate emissions testing regulations on vehicles which he and fellow Republican co-sponsors argue are unnecessary because of advances in automotive fuel efficiency and because testing equipment for mechanics is reportedly obsolete. He also proposed a bill to repeal Pennsylvania’s Frozen Dessert Law and its mandate for monthly testing, finding that the law’s requirements are duplicative with other federal and state regulations. His bill advanced to the Senate and the law was repealed, however, it was accomplished through a similar bill introduced by Senate President Pro Tempore Kim Ward. Wentling voted against each budget last session and he also opposed legislation that funded state-related universities, increasingly targeted by Republicans concerned with rising costs to families, administrative directives on diversity, equity and inclusion as well as abortion-related research. He was among a majority of House Republicans who voted to support bills seeking to enshrine certain protections from the Affordable Care Act into state law should Obamacare be overturned — allowing adult children to remain on their parents’ health policies up to age 26 and also protecting coverage for those with pre-existing conditions. He did not, however, support a third measure seeking to prohibit health insurers from imposing annual or lifetime monetary limits on core benefits of health insurance policies. The bills cleared the House but weren’t considered in the Senate.
After issuing a in September, nonprofit environmental law group Earthjustice filed a against federal agencies involved in the Bitterroot National Forest Plan. The complaint, filed on Tuesday, criticizes the U.S. Fish and Wildlife Service, U.S. Forest Service and the Bitterroot National Forest for failure to follow guidelines enforced by the Endangered Species Act and seeks to rule the plan as unlawful. The four plaintiffs filing against federal agencies include Friends of the Bitterroot, Friends of Clearwater, Native Ecosystems Council, and the WildEarth Guardians. The lawsuit centers around the Bitterroot Forest Plan amendments’ erasure of road density limitations and how potential new road construction could impact grizzly bear and bull trout population in the Bitterroot. “Plaintiffs thus turn to this Court for relief. To protect grizzly bears and bull trout, Plaintiffs request the Court declare unlawful and vacate the Forest Service’s Programmatic Amendment 40, as well as the 6 underlying Biological Opinion and Environmental Assessment (EA), and remand to the agencies for further analysis,” the complaint reads. Conservation groups took issue with , which allows the Forest Service to, according to the plaintiffs’ (issued on Sep. 10), “open or construct new roads without closing other roads." “Plaintiffs challenge the Forest Service’s 2023 Programmatic Amendment 40 to the Land Management Plan for the Bitterroot National Forest, which eliminated restrictions on road retention and motorized use without adequately considering resulting impacts on grizzly bears and bull trout,” states the complaint. Jim Miller, president of the Friends of the Bitterroot, told the Ravalli Republic in September that road densities in the Bitterroot Forest are “probably the biggest contributor to stream sedimentation, harming trout fisheries.” Besides increasing stream sediment, high road densities could also negatively impact interconnectivity between bear populations, a constant struggle for the state’s already fragmented grizzly population. “Roads displace grizzly bears and degrade bull trout streams” said Ben Scrimshaw, Earthjustice attorney, in a . “The Bitterroot provides crucial connective habitat between grizzly bears in the Northern Continental Divide Ecosystem and the isolated Greater Yellowstone Ecosystem, so allowing for limitless road building and motorized use through this area is a huge step backward in the quest for recovery.” “Grizzly bears require large expanses of intact ecosystem,” Miller told the Ravalli Republic after the lawsuit was filed on Tuesday. “Road densities fragment habitat and compromise the grizzly bear’s ability to inhabit those areas.” Miller mentioned how grizzly bears in Montana have started to trickle back into the Bitterroot and how an increase in road densities could disrupt a gradual reintroduction of the species to the valley. “We see grizzly bears naturally moving into our area,” Miller said. “In order for the Bitterroot ecosystem to be good habitat for grizzly bears, we can’t have too many roads and right now the Bitterroot National Forest has too many roads.” Miller claims that grizzly bears are not recovered enough to be subjected to any kind of human-caused endangerment and that Programmatic Amendment 40 does not adequately analyze the effects of its contents on species like grizzly bears and bull trout. The complaint states that there are two significant ways in which the U.S. Fish and Wildlife Service failed to analyze Programmatic Amendment 40’s impacts on grizzly bears. “(1) it failed to consider road-density impacts on grizzly bears outside of secure, unroaded habitat; and (2) it allowed the Forest Service to overinflate current and future calculations of secure grizzly bear habitat by including fractions of land as small as one acre in size — approximately .00156 square miles,” reads the complaint. These criticisms were also mentioned in the conservation groups’ letter of intent submitted in September. According to Scrimshaw, the lawsuit was not immediately filed after the 60-day-notice transpired because Earthjustice received “last-minute response letters from the agencies.” “It was two letters responding to our 60-day-notice,” Scrimshaw said. “One letter addressed our concerns about impacts to bull trout and the other one was about impacts to grizzly bears.” These response letters are referenced numerous times in footnotes throughout the complaint. “They (federal agencies) said that they would go back and reinitiate consultation on this problem of unauthorized motorized use, which is just a very, very small component of our grizzly bear claims,” Scrimshaw said. “They went through our other arguments and tried to provide rationale, which I didn’t find particularly compelling.” Scrimshaw said these response letters delayed the litigation process because Earthjustice wanted to carefully analyze their contents before proceeding. Relevant responses provided in the agencies’ letters are addressed individually in the lawsuit. Earthjustice highlights discrepancies in each of the responses and provides reasoning as to their failure to address the conservation groups’ complaint. “In response to Plaintiffs’ 60-day notice letter, the agencies asserted that they ‘will examine this issue to determine if further clarification is warranted.’ The agencies did not commit to making any changes and have provided no timeline for completing consultation,” reads one of the footnotes in the complaint. Scrimshaw said that the next step of the legal process involves federal agencies responding to the complaint. “They will submit an answer and we’ll get together with the agencies and work out a case management plan that sets deadlines,” Scrimshaw said. “We’ll get that sorted out together once the agency attorneys have made their appearances in the case; it will be a little bit of a process.”California lawmakers kicked off a special session of the state Legislature Monday. The reason? To fund a $25 million war chest for anticipated legal battles with incoming President Donald Trump’s administration. As nearly 30 new state lawmakers were sworn into office at the state Capitol in Sacramento, legislative leaders gaveled in a special session called by Gov. Gavin Newsom that’s geared toward protecting undocumented immigrants, reproductive rights, climate policy and more from Trump’s second administration. The regular, two-year legislative session also began Monday, but the special session will allow for a speedier lawmaking process. Newsom has requested the funding for the state Department of Justice and other agencies, which are expected to file a flurry of lawsuits challenging Trump policies — as California Democrats did during the president’s first term. The governor’s ask was introduced in bills Monday by Assemblymember Jesse Gabriel, an Encino Democrat who chairs the body’s budget committee. “We will work with the incoming administration and we want President Trump to succeed in serving all Americans,” Newsom said in a statement. “But when there is overreach, when lives are threatened, when rights and freedoms are targeted, we will take action.” Newsom expects to sign the legislation before Trump is sworn in on Jan. 20, and top Democratic lawmakers are on board. They’ll do the bulk of that work in early January after a break, said Assemblymember Marc Berman, a Menlo Park Democrat. “Just like eight years ago, California must once again do everything we can to protect our 39 million residents and our economy,” he said in an email. “During both the special session and the regular session, we must double down on policies to defend reproductive freedom and autonomy, protect the environment, and invest in science and education.” Republicans, however, blasted the special session as a tone-deaf stunt to raise Newsom’s profile as a Trump foil. Politics observers say the Democratic governor almost surely will run for president in 2028, after his final term ends. “Instead of taking the hint that Californians are growing tired of Democrat incompetence, Newsom is doubling down on his extreme agenda and using his special session to ‘Trump-proof’ California with taxpayer dollars,” California GOP Chairwoman Jessica Millan Patterson said in an email. “It’s clear that Gavin Newsom’s 2028 presidential run is now underway, and Californians are simply pawns in his game.” The $25 million set aside for litigation would be a tiny fraction of California’s $288 billion 2024-25 operating budget. But approving that budget required a series of measures to close a $27.6 billion deficit , including dipping into reserves. It was unclear Monday whether funding legal wars with Trump would come at the expense of other programs. On the campaign trail, Trump slammed California as a den of crime, rampant inflation and homelessness, while taking shots at the Golden State’s top Democrats. He also pledged to use the military to conduct mass deportations of immigrants without proper documentation, fueling anxieties of a “worst-case scenario” among Bay Area immigrant advocates . Democrats including U.S. Senator Alex Padilla, Newsom and Attorney General Rob Bonta say they’ll staunchly defend immigrants and will not cooperate with deportations. Bonta also announced Monday that lawmakers are sponsoring bills to ensure Californians can access medication abortions and empowering the attorney general to seek fines from local governments that restrict abortion providers. “I want to make it unequivocally clear: California will remain a safe haven for reproductive rights and access to abortion care, no matter who is in the White House,” Bonta , a potential candidate to succeed Newsom , said in a statement. After Trump’s victory last month, Newsom and California Democrats quickly laid the groundwork to oppose the incoming Republican administration. It’s a reprise role. During Trump’s first term, California filed 122 lawsuits challenging his administration’s policies under Democratic Attorney General Xavier Becerra. That litigation cost the state $42 million, according to Newsom’s office, and netted some victories. In one case, California and New York successfully sued the U.S. Department of Energy in 2017 to allow energy efficiency standards to go into effect nationally, which were expected to save consumers $8.4 billion and prevent nearly 100 million tons of greenhouse gas emissions. Another victory won California $60 million in federal public safety grants, the governor’s office said. Once again, California’s stand-off with Trump is likely to be a major force in state politics for the next four years. But this time around, Newsom is stressing that he’s open to finding common ground with the former president. Meanwhile, Assembly Speaker Robert Rivas and Senate President Pro Tem Mike McGuire say they’ll be mostly be focusing not on resisting Trump, but making California more affordable, CalMatters reported . In fact, Newsom and Rivas have made overtures to California voters since Republicans nationally swept the November elections, reclaiming the White House and Senate and holding the House of Representatives. He made gains throughout the state in part because of discontent over inflation and living costs. In response, Newsom is touring conservative counties to highlight an economic development plan and has said that Democrats need to focus more on the economy. A spokesperson for Rivas did not return a request for comment by press time. Nearly 30 new lawmakers were also sworn in at the state Capitol on Monday. The new legislature includes a record-breaking number of women — 59 of its 120 members, one seat shy of the same number as men . Democrats still have a complete control on state government, with supermajorities in both chambers of the legislature and holds on all executive seats.MILAN, Italy (AP) — Atalanta went to the top of Serie A when Ademola Lookman scored with three minutes remaining to beat AC Milan 2-1 on Friday. Atalanta’s ninth win in a row was a fitting gift to coach Gian Piero Gasperini, who was awarded the coach of the month award earlier in the day for guiding his team to a perfect record in November. Charles De Ketelaere put the home side ahead with a towering header after 11 minutes only for Milan to level 11 minutes later. Theo Hernández released Rafael Leão on the right wing and his inviting cross was converted by Álvaro Morata. Milan, which lost Christian Pulišić to a knock before halftime, looked set to end Atalanta’s impressive run but Lookman nipped in at the back post to nod home a corner in the dying moments. Atalanta has 34 points, two more than Napoli, which has a game in hand against Lazio on Sunday. Milan was in seventh place. Serie A champion Inter defeated Parma 3-1 and extended the Milan club’s unbeaten run to 13 games. Federico Dimarco put the home side ahead five minutes before halftime when he worked a neat one-two with Henrikh Mkhitaryan and fired a low shot past Zion Suzuki. Nicolò Barella made it two eight minutes into the second half when he finished a fast counterattack with aplomb. Marcos Thuram's 10th goal of the season made it 3-0 in the 66th. A Matteo Darmian own goal gave some late consolation for Parma. AP soccer: https://apnews.com/hub/soccer
Michigan Trolls Ohio State by Reposting Final Score with Subtle TwistFrom Decline to Dignity – Restoring Parliament’s GreatnessAlabama A&M fires football coach Connell Maynor after 7 seasonsCHANDLER, Ariz., Dec. 02, 2024 (GLOBE NEWSWIRE) -- (NASDAQ:MCHP) – Microchip Technology Incorporated, a leading provider of smart, connected, and secure embedded control solutions, today announced that the Company will present at the UBS Global Technology and AI Conference on Tuesday, December 3, 2024 at 3:35 p.m. (Mountain Time). Presenting for the Company will be Mr. Steve Sanghi, President and Chief Executive Officer. A live webcast of the presentation will be made available by UBS, and can be accessed on the Microchip website at www.microchip.com . Any forward looking statements made during the presentation are qualified in their entirety by the discussion of risks set forth in the Company's Securities and Exchange Commission filings. Copies of SEC filings can be obtained for free at the SEC's website ( www.sec.gov ) or from commercial document retrieval services. Microchip Technology Incorporated is a leading provider of smart, connected and secure embedded control solutions. Its easy-to-use development tools and comprehensive product portfolio enable customers to create optimal designs, which reduce risk while lowering total system cost and time to market. The company's solutions serve approximately 125,000 customers across the industrial, automotive, consumer, aerospace and defense, communications and computing markets. Headquartered in Chandler, Arizona, Microchip offers outstanding technical support along with dependable delivery and quality. For more information, visit the Microchip website at www.microchip.com . Note: The Microchip name and logo are registered trademarks of Microchip Technology Inc. in the USA and other countries. INVESTOR RELATIONS CONTACT: Deborah Wussler ......... (480) 792-7373
Disney’s streaming business now profitable, possibly signaling a turning point
December 6, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Kyushu University Researchers at Kyushu University have revealed how spatial distance between specific regions of DNA is linked to bursts of gene activity. Using advanced cell imaging techniques and computer modeling, the researchers showed that the folding and movement of DNA, as well as the accumulation of certain proteins, changes depending on whether a gene is active or inactive. The study, published on December 6 in Science Advances , sheds insight into the complicated world of gene expression and could lead to new therapeutic techniques for diseases caused by improper regulation of gene expression. Gene expression is a fundamental process that occurs within cells, with two main phases: transcription, where DNA is copied into RNA, and translation, where the RNA is used to make proteins. For each cell to carry out its specific functions in the body, or to respond to changing conditions, the right amount of a protein must be produced at the right time, meaning genes must be carefully switched on and off. Previously, gene transcription was thought to occur in a continuous, smooth process. But with better technology to observe individual cells , scientists now know that transcription occurs in short, unpredictable bursts. "A gene will randomly switch on for a few minutes and large amounts of RNA will be produced. Then, the gene will suddenly switch off again," says Professor Hiroshi Ochiai, from Kyushu University's Medical Institute of Bioregulation and the study's senior author. "It happens in nearly all genes, and in all living things, from plants, to animals, to bacteria." This erratic and dynamic nature of transcription, known as transcriptional bursting, is a key mechanism for controlling gene activity in individual cells. It's one reason why cells within the same tissue or culture environment show variability in their gene expression levels, which is crucial for processes like early embryonic development and cancer evolution. However, the exact mechanisms behind bursting remains unknown. In this study, the researchers decided to look into the role of DNA sequences known as enhancers and promoters, and how their spatial distance impacts transcriptional bursting. The promoter is usually located right next to the gene, and is where the protein that carries out transcription attaches to the DNA. Enhancers, on the other hand, are often many hundreds of thousands of bases away from the gene, but as DNA strands move and fold, enhancers can still end up close to genes in 3D space, amplifying gene activity. "We believe that enhancers play a crucial role in why transcription occurs in bursts of activity, but so far, the research is unclear," says Ochiai. To test this idea, Ochiai and his team used an advanced imaging technique called seq-DNA/RNA-IF-FISH, which labels DNA, RNA and specific proteins with fluorescent probes. This triple-layered technique allowed the researchers to simultaneously capture the location of DNA, RNA and specific proteins in 3D space within individual mouse embryonic stem cells. With that information, the team could determine whether certain genes were on or off, see how the promoters and enhancers were interacting during bursts of activity, and where the proteins were accumulating, at an unprecedented level of detail. As an example, the researchers focused on a gene called Nanog, a 770,000-base length of DNA on chromosome 6, which has a promoter and three enhancer regions and is known to undergo transcriptional bursting in cultured mouse embryonic stem cells. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . The researchers found that in imaged cells where Nanog RNA was present (meaning the gene was active), the most distant enhancer was located in close spatial proximity to the Nanog gene. In contrast, when Nanog was inactive, the imaging showed that the same enhancer region was physically further away. Additionally, the scientists also found that proteins involved in regulating transcription also accumulated in the area around the enhancers and promoters when Nanog was active. To better understand the mechanism, Ochiai and his team used computer modeling to simulate how the different parts of DNA interact and move inside the cell, both when the Nanog gene is active and inactive. They developed their model by using data from their imaging experiments to make a "map" of how frequently different regions of DNA interacted with each other and how the DNA was folded in space. Using this map, the model then simulated how the DNA chain might randomly move. The model predicted that when in the active state , each enhancer region interacted for more than twice as long with the promoters, compared to when the gene was inactive. The model showed that these longer periods of interaction occurred due to "friction" around the DNA. Due to the accumulation of proteins and RNA when Nanog was active, the fluid became more viscous, and caused the modeled DNA strand to move slowly. Therefore, the gene was able to stay active for longer bursts of time. In contrast, the simulated DNA moved quicker when Nanog was inactive, meaning that the promoter and enhancers didn't have time to interact. "The modeling suggests that bursting is stabilized due to these reinforcing loops," concludes Ochiai. "Of course, this is just a simulation. The next step is to prove this mechanism also occurs in cells." More information: Hiroaki Ohishi et al, Transcription-coupled changes in genomic region proximities during transcriptional bursting, Science Advances (2024). DOI: 10.1126/sciadv.adn0020 . www.science.org/doi/10.1126/sciadv.adn0020 Journal information: Science Advances Provided by Kyushu University
Shanghai Fosun Pharmaceutical (2196) is proceeding with its proposal to merge and privatize innovative drug-maker Shanghai Henlius Biotech (2696) at a cost of HK$5.4 billion. Following an announcement in June, Fosun Pharma said yesterday it has dispatched a composite document outlining the merger details to overseas shareholders. The company proposes to pay HK$24.6 for each Henlius' share listed in Hong Kong, 36.67 percent higher than the closing price of HK$18 on May 21. Henlius last traded at HK$23.9 per share on December 20. An extraordinary general meeting and a meeting for H shareholders will be held on January 22, 2025. Fosun Pharma is also the controlling shareholder of Henlius Biotech and, together with its other affiliates, owns 65.23 percent in the Hong Kong-listed drugmaker. It comes as the parent Fosun International (0656) continues to consolidate its portfolio of a diverse set of companies operating businesses from retail to real estate. Earlier this month, Fosun Tourism (1992) proposed to buy back shares not owned by its controlling shareholder, in a bid to take itself private and address concerns about the limited liquidity of its stock. Staff reporter and ReutersPete Hegseth's Mom Called Him An 'Abuser Of Women' In Email: ReportBiden's broken promise on pardoning his son Hunter is raising new questions about his legacy WASHINGTON (AP) — President Joe Biden’s decision to go back on his word and pardon his son Hunter wasn't all that surprising to those who are familiar with the president's devotion to his family. But by choosing to put his family first, the 82-year-old president has raised new questions about his legacy. Biden has held himself up as placing his respect for the American judicial system and rule of law over his own personal concerns. It was part of an effort to draw a deliberate contrast with Republican Donald Trump. Now, both his broken promise and his act of clemency are a political lightning rod. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Success! An email has been sent to with a link to confirm list signup. Error! There was an error processing your request. Get the latest need-to-know information delivered to your inbox as it happens. Our flagship newsletter. Get our front page stories each morning as well as the latest updates each afternoon during the week + more in-depth weekend editions on Saturdays & Sundays.
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Reigning pairs world champions Deanna Stellato-Dudek and Maxime Deschamps will lead Canada's contingent into next week's ISU Grand Prix of Figure Skating Final. Stellato-Dudek, who is from Chicago but representing Canada, and Deschamps, from Vaudreuil-Dorion, Que., enter the event scheduled for Dec. 5-8 in Grenoble, France, as the top-ranked pairs team. The duo posted wins at both their appearances on the circuit this season, topping the podium at Skate Canada International and the Finlandia Cup. Stellato-Dudek and Deschamps took the bronze medal at last year's Grand Prix final. WATCH | Stellato-Dudek, Deschamps earn Finlandia Cup gold: Another Grand Prix series win for Canada's Stellato-Dudek and Deschamps, this time in Finland 9 days ago Duration 7:58 Deanna Stellato-Dudek and pairs partner Maxime Deschamps skated to a winning score of 207.44 to win the Finlandia Trophy pairs title in Helsinki Sunday. Ice dancers Piper Gilles of Toronto and Paul Poirier of Unionville, Ont., return to the final after placing third in 2023 and will be joined by Marjorie Lajoie of Boucherville, Que., and Zachary Lagha of St-Hubert, Que. Gilles and Poirier won gold at Skate Canada and silver at Finlandia, while Lajoie and Lagha won silver at Skate Canada and silver at the Cup of China. In junior competition, Jazmine Desrochers of Mississauga, Ont., and Kieran Thrasher of Amherstburg, Ont., will compete in ice dance while Julia Quattrochi of Laval, Que., and Simon Desmarais of Carignan, Que., skate in pairs. WATCH | Gilles, Poirier claim ice dance silver in Helsinki: Canada's Gilles and Poirier settle for silver medal at Finlandia Trophy 9 days ago Duration 9:40 Piper Gilles and Paul Poirier of Canada skated to a final score of 200.79 Sunday at the Finlandia Trophy good enough for a silver medal.
Zomato, Zerodha founders back Aakash Chaudhry's edtech comeback Sparkl EdventureBiden's Unconditional Pardon: A Controversial MoveEDMONTON — Alberta Transportation Minister Devin Dreeshen says as of April 1 the province is ending photo radar ticketing on all numbered provincial highways. The province also plans over the coming months to review "cash cows” – photo radar spots that appear to prioritize money-making over safety -- with the goal of shutting down 70 per cent of the current 2,200 sites. Dreeshen says far too often photo radar penalizes drivers without improving road safety, adding the province doesn’t intend to offer extra cash to make municipalities whole from the lost photo radar revenue. “The whole point of getting rid of these cash cow locations is to make sure that photo radar is used as a traffic safety tool and not as a revenue generator,” Dreeshen told a news conference Monday. Photo radar will continue to be allowed in school zones, playground zones and construction sites, but beyond these areas, local governments will have to submit their case and show evidence of higher collision rates. At intersections equipped with cameras, running a red light could still net a driver a ticket, but speeding on green will not - starting in the spring. Kara Westerlund, president of the Rural Municipalities of Alberta, applauded the move. “Our communities have called for change, and I’m proud to say that this government has listened,” she said at the government news conference. Alberta Municipalities president Tyler Gandam said his organization supports local governments using automated traffic enforcement for safety reasons, since the data shows it reduces deaths, injuries and property damage. "It's improving safety in the communities, no question," Gandam said in an interview, adding the government's decision is about political points because getting tickets is unpopular. "If you don't like photo radar, just stop speeding," he said. Gandam said forcing municipalities to go through another approval process represents more bureaucracy from a government that prides itself on cutting red tape. He said photo radar revenue makes up a small portion of any municipality's budget. For him, the issue is about safety, including that of the police officers who will need to enforce traffic safety. Dreeshen said the province has seen a "mixed bag" of data measuring photo radar's effect on collision numbers. "There's lots of folks that will say photo radar is needed to keep these streets safe, but we've also seen municipalities, when they remove photo radar, that we've actually seen safer streets," he said. "We're not banning speed limits," he said. Opposition NDP critic Lorne Dach told reporters Dreeshen's move doesn't appear to be supported by evidence. "The decision-making here seems to be basically based on the minister's decision about popularity rather than public safety data," said Dach. NDP Leader Naheed Nenshi said the government is adding red tape, and that municipalities, including Calgary, use photo radar funding to pay for policing. "If this government wants municipalities to increase property taxes for their largest budget item, they should just say so," he said. The United Conservative Party government has been placing restrictions on photo radar sites in stages. All photo radar sites were removed from ring roads in Calgary and Edmonton last December. Dreeshen said that's shown good results, in part because drivers aren't taken off guard by having to suddenly slow down and disrupt traffic. In 2019, the UCP increased the province’s share of photo radar revenue to 40 per cent from 27. That fiscal year, the revenue generated was $203 million across the province. By last year, total revenue was down to $145 million, Dreeshen said Monday. "At the end of the day, this is going to be a hit to the province (financially) as well." Among the top five revenue-generating sites listed by the government in 2023, four are in Edmonton and area, each collecting between $2.1 million and almost $6 million per year. This report by The Canadian Press was first published Dec. 2, 2024. Lisa Johnson, The Canadian Press
Yoon right about pro-North Korea influences in South’s parliamentHUNTSVILLE, Ala. (AP) — Alabama A&M fired football coach Connell Maynor after seven seasons on Monday. Athletic director Paul A. Bryant announced the decision in a statement. The Bulldogs went 6-6 this season, including a 4-4 Southwestern Athletic Conference mark, and won three straight games before a season-ending loss to Florida A&M. Maynor finished 40-32 at Alabama A&M, including a 28-21 SWAC record. Maynor led Alabama A&M to its first SWAC championship in 15 years during the shortened 2021 season that played in the spring. The Bulldogs went 5-0 and beat Arkansas-Pine Bluff 40-33 to claim the program's second SWAC football title. Maynor is a former Arena Football League player who played quarterback for Winston-Salem State and North Carolina A&T. The program suffered a tragedy when linebacker Medrick Burnett Jr. died last week from an injury sustained during the annual Magic City Classic against in-state rival Alabama State on Oct. 26. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football
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