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Brain inflammation alters behavior according to sex, mouse study finds December 19, 2024 University of Technology Sydney Inflammation in the hippocampus -- the brain's memory center -- significantly alters motivation and behavior in mice, according to new research. Facebook Twitter Pinterest LinkedIN Email Inflammation in the hippocampus -- the brain's memory centre -- significantly alters motivation and behaviour in mice, including food-seeking behaviour, with notable differences between males and females, a recent study reveals. The hippocampus plays a crucial role in memory formation, learning and emotional regulation. Hippocampal neuroinflammation occurs in a range of diseases and disorders such as Alzheimer's, Multiple Sclerosis and Depression. People with these diseases often experience common symptoms such as apathy, difficulty with daily activities and changes to food preferences. These symptoms also tend to be more severe in women than in men. "While inflammation in the hippocampus is not solely responsible for behaviour changes, it likely triggers wider brain activity that influences behaviour," said study co-author Dr Laura Bradfield, Director of the Brain and Behaviour Lab at the University of Technology Sydney (UTS). "This research suggests that treatments targeting hippocampal neuroinflammation could help reduce cognitive and behavioural symptoms in these diseases and improve brain health, especially in women," she said. The study, "Hippocampal neuroinflammation induced by lipopolysaccharide causes sex-specific disruptions in action selection, food approach memories, and neuronal activation," was published in the journal Brain Behavior and Immunity . Researchers induced inflammation by exposing mouse hippocampal cell cultures in the lab to lipopolysaccharide, a bacterial toxin that elicits a strong immune response. They found the toxin only activated neurons in the presence of other types of brain cells such as microglia and astrocytes. This highlights the complex interaction between different cell types during inflammation. To examine behaviour, the researchers injected lipopolysaccharide directly into the hippocampus of mice and observed their activity and food-seeking behaviours. They discovered that neuroinflammation increased movement and activity levels in both sexes but had a more pronounced effect on food-seeking behaviours in females. Lead author Dr Kiruthika Ganesan, who recently completed her PhD at UTS, said the study underscores the importance of considering sex-specific effects when developing treatments for neurological diseases. "These findings provide fresh insights into how neuroinflammation affects brain function, potentially paving the way for new therapies that address the behavioural and cognitive symptoms of a range of diseases," she said. "We hope that future research will focus on understanding the mechanisms behind these sex-specific effects, including the influence of hormones such as estrogen, and their implications for brain health." Story Source: Materials provided by University of Technology Sydney . Note: Content may be edited for style and length. Journal Reference : Cite This Page :Star Trek 's Harry Kim was done dirty by Voyager many times throughout the series. He was killed, given an alien disease, and, worst of all, remained at the rank of Ensign for the entirety of the series. So, when CinemaBlend spoke to actor Garrett Wang about his feelings during that at the time, he was candid about how displeased he was, how his perspective changed over time, and how he made a wild plea to Kate Mulgrew. I had a chance to talk to Wang ahead of his return in the Star Trek: Lower Decks episode "Fissure Quest" (which you can stream now with a Paramount+ subscription ), and we also chatted about the past WTF moments of Voyager as well as Harry never being promoted. Even though it was a character on the show, I asked the actor if he ever felt "miffed" about Harry never moving to that next level. To my mild surprise, he was so worked up about it that he ended up outside Kate Mulgrew's trailer at one point. Here's what he said: I was miffed for a very long time. I was miffed for a very, very long time. I remember knocking on Kate Mulgrew's trailer door, pleading to the actress playing the captain to promote me. I said, ‘This is ridiculous. I haven't been promoted yet. I've done all these things for the crew. I've helped save the day a few times.’ And Kate was like, ‘I know, I know.’ So she was sympathetic, but silly me, I was so desperate. I went to the actress playing the role of captain to try to get promoted. And so yeah, I was miffed in the beginning. Mulgrew was at the top of the call sheet, but even then, she was also working at the will of the writers and the showrunner. Unlike upcoming Trek shows , the largely episodic structure of The Next Generation era meant maintaining the status quo. However, even then, the series found a way to demote and reinstate Tom Paris, so I can understand why Garrett Wang was so frustrated. Given that, one might think Star Trek: Lower Decks ' "Fissure Quest" so directly poking fun at the multiverse of Harrys being shocked over one's promotion might sting a little. However, Wang assured me that's not the case these days, and he learned to embrace that part of his character that made him stand out among some of the best Star Trek characters out there: I learned to accept it. And that's the lesson there for all human beings that we're all in a situation at one point or another. Whether it's work or school where we're stuck in a rut where we're not advancing and we're feeling like everything is against us. And that's truly Harry. Harry is the punching bag of Voyager. Harry is the Rodney Dangerfield of Voyager. 'No respect,' for those of you out there who understand that reference. As time went on, I accepted it and realized that, 'Hey, this happens to Harry, and it happens to people in real life. And what do you do? You could sit there and complain about it and get gray hairs over it or get over it.' Because that's the thing: stress and trauma cause illness in the body, right? Or, you can go with the flow, and I've actually owned it to the point where my tag whenever I play any online games and my gamer name is Forever Ensign. So, I have already adopted it. I've embraced it. It's of little surprise to me that Lower Decks creator Mike McMahan helped create a script that Garrett Wang was comfortable with and was the first to feature the character again in the new era. That said, the actor did confirm to CinemaBlend that it wasn't his first invite back to Star Trek , but that's all we know about that. Star Trek: Lower Decks' Jerry O'Connell Shared A Cryptic Response When Asked About Not Being In The Strange New Worlds Crossover, And Now I'm Curious Harry Kim was the villain of sorts in Star Trek: Lower Decks ' "Fissure Quest," but he was also the hero. A promoted Harry attempted to transport all the other Harrys to his universe where they could be their best selves, only to be thwarted by his other selves because none of them wanted that. Sure, the acknowledgment of hard work would've been nice, but in a post-scarcity society how much should people value a promotion? They're all getting a meal of their choosing from the replicator the same as anyone else, so maybe rank and prestige aren't so valuable until it gets to a certain point. Maybe the finale of Star Trek: Lower Decks will go deeper on that idea too, because if I've learned anything, it's to expect the well-thought-out unexpected with this show. CINEMABLEND NEWSLETTER Your Daily Blend of Entertainment News Catch the finale of Lower Decks when it airs on the 2024 TV schedule Thursday, December 19th on Paramount+. I'm thrilled to see the conclusion of the series, though I have to say it would be more thrilling to see the series get picked up by another streamer and make a big return.
ABU DHABI , UAE , Dec. 19, 2024 /PRNewswire/ -- ADGM, the leading international financial centre of Abu Dhabi and a globally recognised hub for asset and wealth management unveiled nineteen major announcements from global financial institutions during the third edition of ADFW. These represent almost USD 635 billion in assets under management (AUM) and follow other Q4 announcements from the world's largest asset managers, BlackRock, PGIM, and Nuveen, which have also been set up in ADGM. This remarkable increase, from USD 450 billion to USD 635 billion , within a year has reinforced the centre's reputation as the region's fastest-growing and one of the world's most dynamic jurisdictions for asset management. This growth has been further bolstered by the establishment of billionaire-led family offices, including those of British businessman Asif Aziz , prominent philanthropist and financial strategist Wafic Said , and Singaporean entrepreneur and real estate leader Kishin RK, underscoring the centre's growing appeal as a global wealth management hub. Commenting on Abu Dhabi and ADGM's continued momentum, H.E. Ahmed Jasim Al Zaabi , Member of Abu Dhabi's Executive Council & Chairman of the Abu Dhabi Department of Economic Development (ADDED) and ADGM said, "These milestones reflect the heart of what makes Abu Dhabi so special—a shared vision of progress, partnership, and possibility. The growing number of global financial leaders and innovators choosing ADGM is a testament to the trust they place in our infrastructure, robust regulations, commitment to excellence and Abu Dhabi's reputation as the world's safest and most dynamic jurisdiction for asset and wealth management. As we welcome these new partnerships, we remain dedicated to driving the growth and diversification of the 'Falcon Economy' and creating opportunities that resonate across industries and borders. It's an exciting moment for ADGM, Abu Dhabi , and all those who are part of this remarkable journey." Larry Fink , Chairman and CEO of Blackrock praised Abu Dhabi commenting, "It's been a long journey watching how Abu Dhabi has matured as an economy. The constant innovation that I'm seeing from the economy and from the leadership. And Abu Dhabi has really positioned itself to become a leader over the next 20 years. Its psychology was different, and now it's blossoming into this magnet of opportunity. With that strength, it is now becoming a foundation for innovation." "We see a real burgeoning of entrepreneurship happening in the region and believe that the Middle East is the next big entrepreneurial hot spot. We've watched this happen before and always had our eye out on areas emerging in terms of entrepreneurship," said Bill Ford , Chairman & CEO of General Atlantic , during the second day of ADFW. Sir Paul Marshall , Chairman and Chief Investment Officer of Marshall Wace said, " Abu Dhabi is such a great place. Abu Dhabi is absolutely nailing it. It's a very attractive place." Confirming their establishment in ADGM during ADFW were leading private equity firms General Atlantic, Lone Star Funds, and Investindustrial along with private credit giants Golub Capital and Polen Capital, insurance manager – Eldridge as well as leading global equity management company, Carta and hedge fund Marshall Wace . This recent wave of commitments from global financial institutions signifies ADGM's leadership in attracting the world's foremost investment firms. Reflecting this confidence and growth, billionaire-led family offices have also been drawn to ADGM, recognising it as a trusted hub for managing and growing wealth. Asif Aziz , Founder and CEO of Criterion Capital commented, " Abu Dhabi's transformation into a global financial powerhouse makes it an ideal base for our operations. ADGM's world-class infrastructure and strategic location provide unparalleled opportunities to forge partnerships that align with our growth ambitions across the UAE and beyond." Building on its role as a leading destination for global investors and asset managers, ADGM is also redefining financial innovation by advancing its digital ecosystem. A cornerstone of this effort was the launch of Finstreet, a first-of-its-kind international securities market and an ecosystem for private securities, which exemplifies ADGM's commitment to integrating cutting-edge digital solutions with its robust financial infrastructure. The week also saw a new funding round for Themis and the entry of international digital pioneers Zodia Markets, Polygon Labs, FJ Labs, Aptos Digital, Chainlinks, Astra Tech and Themis, further solidifying the Emirate's reputation as a global innovation hub. Meanwhile, FinTech Astra Tech's Quantix announcement of a landmark USD 500 million financing from Citigroup, among the largest provided to a UAE FinTech company to date, to expand its CashNow consumer lending platform. Additionally, Themis—renowned for its advanced financial crime prevention technologies—is further reinforcing ADGM's position as a hub for the next generation of financial technologies, secured over USD 9.75 million in scale-up funding, building on its success in partnerships with global leaders, including ADGM underscoring its role in advancing financial crime prevention in innovative regulatory environments. The market announcements were released during the third edition of ADFW held under the theme "Welcome to the Capital of Capital," which gathered more than 20,000 leaders and executives from across the financial services industry, which collectively represented more than USD 42 trillion in assets under management. This wave of newcomers ADFW underscores Abu Dhabi's position as a global financial powerhouse and ADGM's role as a catalyst for economic diversification, attracting top-tier talent, cutting-edge technologies, and transformative investments that are shaping the emirate's future. Logo - https://mma.prnewswire.com/media/2550581/5010772/ADGM_Logo.jpg View original content: https://www.prnewswire.com/news-releases/aum-of-usd-635-billion-at-adfw-caps-stellar-q4-as-trillion-dollar-club-flock-to-adgm-302336607.html SOURCE ADGM
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United v Arsenal, City face class of 92 in FA Cup third round, Perez leaving Red BullCyber Monday shoppers expected to set a record on biggest day for online shoppingFacebook Twitter WhatsApp SMS Email Print Copy article link Save NASHVILLE, Tenn. — Married couples across the U.S. have had access to no-fault divorce for more than 50 years, an option many call crucial to supporting domestic abuse victims and key to preventing already crowded family courts from drowning in complicated divorce proceedings. But some advocates for women worried as old comments from now Vice President-elect JD Vance circulated during the presidential campaign opposing no-fault divorce. After President-elect Donald Trump and Vance won the election, warnings began popping up on social media urging women who might be considering divorce to "pull the trigger" while they still could. Some attorneys posted saying they saw a spike in calls from women seeking divorce consultations. Donald and Ivana Trump pose in May 1988 outside the Federal Courthouse in New York after she was sworn in as a United States citizen. Trump — who is twice-divorced — hasn't championed overhauling the country's divorce laws, but in 2021 Vance lamented that divorce is too easily accessible, as have conservative podcasters and others. People are also reading... City officials admit Corvallis' flag is 'bad.' Will it change? 2 bucks illegally killed with crossbow in Corvallis The real reason Corvallis' Pastega Lights moved to Linn County OSU football: Three takeaways from Oregon State's loss at Boise State Commentary: Gulbranson shows he should be starter in thrilling win over Cougars Head-on crash on Highway 228 kills 1, injures 2 Linn County deputy resigns during menacing case More allegations against ex-OSU coach Prosecutor: Driver on laughing gas caused double fatal in Sweet Home Corvallis homes in on layout options for a new government center Corvallis man gets prison for armed robbery case OSU football: Boise State's pass rush is formidable A busy day: A series of crashes in Sweet Home OSU football: Preview and prediction for regular-season finale against Boise State OSU football: Game notes for the Beavers' win over Washington State "We've run this experiment in real time and what we have is a lot of very, very real family dysfunction that's making our kids unhappy," Vance said during a speech at a Christian high school in California, where he criticized people being able to "shift spouses like they change their underwear." Marriage rates held steady but divorce rates of women age 15 and older declined from 2012 to 2022, according to U.S. Census Bureau data released in October. Despite concerns, even those who want to make divorces harder to get say they don't expect big, swift changes. There is not a national coordinated effort underway. States determine their own divorce laws, so national leaders can't directly change policy. "Even in some of the so-called red states, it hasn't gotten anywhere," said Beverly Willett, co-chair of the Coalition for Divorce Reform, whose group unsuccessfully attempted to convince states to repeal their no-fault divorce laws. A couple exchanges wedding bands Oct. 11, 2018, at City Hall in Philadelphia. Mark A. Smith, a political science professor at the University of Washington, said while many Americans became accustomed to no-fault divorce being an option, Vance's previous comments on making it more difficult to separate from a spouse could help jump-start that effort. "Even though he's not directly proposing a policy, it's a topic that hasn't gotten a ton of discussion in the last 15 years," Smith said. "And so to have a national profile politician talk that way is noteworthy." Meanwhile, Republican Party platforms in Texas and Nebraska were amended in 2022 to call for the removal of no-fault divorce. Louisiana's Republican Party considered something similar this year but declined to do so. A handful of proposals were introduced in conservative-led statehouses over the years, but all immediately stalled after they were filed. In January, Oklahoma Republican Sen. Dusty Deevers introduced legislation that would have removed married couples from filing for divorce on the grounds of incompatibility. Deevers backed the bill after writing a piece declaring no-fault divorce was an "abolition of marital obligation." Sen. JD Vance smiles as his wife Usha Vance applauds Nov. 6 at an election-night watch party at the Palm Beach Convention Center in West Palm Beach, Fla. Similarly, in South Carolina, two Republican lawmakers in 2023 filed a bill that would have required both spouses to file for a no-fault divorce application rather than just one. In South Dakota, a Republican lawmaker attempted to remove irreconcilable difference as grounds for divorce since 2020. None of the sponsors of these bills responded to interview requests from The Associated Press. All are members of their state's conservative Freedom Caucus. Nevertheless, some Democratic lawmakers say they remain worried about the future of no-fault divorce. They point to the U.S. Supreme Court overturning the constitutional right to abortion in 2022 as an example of a long-accepted option that was revoked through a decades-long effort. "When you choose to be silent, you allow for this to creep in," said Democratic South Dakota Rep. Linda Duba. "These are the bills that gain a foothold because you choose to be silent." Before California became the first state to adopt a no-fault divorce option in 1969, married couples had to prove their spouse violated one of the approved "faults" outlined in their state's divorce law or risk a judge denying their divorce, said Joanna Grossman, a law professor at Southern Methodist University in Dallas. Qualified reasons varied from state to state, but largely included infidelity, incarceration or abandonment. Donald and Marla Trump wave to photographers Dec. 20, 1993, as they enter their wedding reception in New York's Plaza Hotel. The system was a particular burden on domestic violence victims, who are often women who could be stuck in dangerous marriages while they try to prove their partner's abuse in court through expensive and lengthy legal proceedings. "If there was any evidence that the couple both wanted to get divorced that was supposed to be denied because divorce was not something you got because you wanted it, it was something you got because you've been wronged in a way that the state thought was significant," Grossman said. To date, every state in the U.S. adopted a no-fault divorce option. However, 33 states still have a list of approved "faults" to file as grounds for divorce — ranging from adultery to felony conviction. In 17 states, married people only have the option of choosing no-fault divorce to end their marriages. The Most Divorced Cities in the U.S. The Most Divorced Cities in the U.S. Photo Credit: shisu_ka / Shutterstock Marriage—and divorce—in the U.S. today are starkly different than in earlier eras of the country’s history. A series of economic, legal, and social shifts reshaped marriage in the second half of the 20th century. More women began working outside of the home in the post-World War II era, which provided avenues to financial security and independence outside of marriage. Greater emphasis on postsecondary educational attainment and career development have led young people to wait longer to enter marriage. States began to adopt no-fault divorce laws throughout the 1960s and 1970s that made it easier to end a marriage. Meanwhile, changing social and cultural attitudes have made it more common for couples to cohabitate, combine finances, and raise children prior to getting married—or without getting married at all. These trends have contributed to a decline in the overall number of marriages and to delays in when people get married for the first time. In the U.S., there are currently only 6.5 marriages per 1,000 people each year , compared to 10.9 five decades ago. For those who do choose to get married, the age of first marriage is happening later. As late as the early 1970s, the median age for a first marriage in the U.S. was just 22. By 2018, that figure had increased to 28.8. These shifts have also affected how likely married couples are to stay together. As women entered the workforce in the mid-20th century and feminism and the sexual revolution took hold, rates of divorce rose quickly throughout the 1960s and 1970s. From 1960 to 1980, the divorce rate per 1,000 people in the U.S. more than doubled from 2.2 to 5.2. But the rate began to fall steadily after 1980, and as of 2018, the rate of divorce had dropped to 2.9 per 1,000 people. Divorce rates have declined alongside increasing marriage ages since the 1980s The link between rates of divorce and age at first marriage has been borne out over time, but it also explains geographic differences in rates of divorce. Today, most of the states with the lowest rates of divorce are also those with a higher median age for marriage. States like New Jersey, New York, California, and Massachusetts all stand out for having fewer than 10% of adults divorced and an age at first marriage above 30. One exception to this is Utah, which has the lowest overall median age for first marriage at 25.5 but also the third-lowest share of divorced adults at 9%, likely due in part to the state’s strong religious ties to the Church of Jesus Christ of Latter-day Saints . In contrast, Maine and Nevada lead all states in the share of the population currently divorced at 13.9% and 13.8%, respectively. And at the local level, many of the cities with the highest levels of divorce are found in Florida, Appalachia, and the Southwest. Maine and Nevada have the highest proportions of adults currently divorced The data used in this analysis is from the U.S. Census Bureau’s 2020 American Community Survey . To determine the most divorced locations, researchers at ChamberOfCommerce.org calculated the percentage of adults currently divorced. In the event of a tie, the location with the higher percentage of adults currently separated was ranked higher. To improve relevance, only cities with at least 100,000 residents were included. Additionally, cities were grouped into cohorts based on population size: small (100,000–149,999), midsize (150,000–349,999), and large (350,000 or more). Here are the most divorced cities in the U.S. Small and midsize cities with the most divorced adults 15. Aurora, CO Photo Credit: Jacob Boomsma / Shutterstock Percentage of adults currently divorced: 12.7% Percentage of adults currently separated: 2.0% Percentage of adults currently married: 46.1% Percentage of adults never married: 34.9% 14. New Orleans, LA Photo Credit: Sean Pavone / Shutterstock Percentage of adults currently divorced: 12.8% Percentage of adults currently separated: 2.7% Percentage of adults currently married: 28.5% Percentage of adults never married: 50.3% 13. Oklahoma City, OK Photo Credit: Sean Pavone / Shutterstock Percentage of adults currently divorced: 12.9% Percentage of adults currently separated: 2.3% Percentage of adults currently married: 45.1% Percentage of adults never married: 34.2% 12. Colorado Springs, CO Photo Credit: photo.ua / Shutterstock Percentage of adults currently divorced: 13.0% Percentage of adults currently separated: 1.5% Percentage of adults currently married: 49.9% Percentage of adults never married: 31.1% 11. Louisville/Jefferson County, KY Photo Credit: Jonny Trego / Shutterstock Percentage of adults currently divorced: 13.0% Percentage of adults currently separated: 2.0% Percentage of adults currently married: 41.9% Percentage of adults never married: 36.6% 10. Kansas City, MO Photo Credit: Tupungato / Shutterstock Percentage of adults currently divorced: 13.3% Percentage of adults currently separated: 2.2% Percentage of adults currently married: 39.7% Percentage of adults never married: 39.7% 9. Wichita, KS Photo Credit: Sean Pavone / Shutterstock Percentage of adults currently divorced: 13.5% Percentage of adults currently separated: 1.9% Percentage of adults currently married: 45.9% Percentage of adults never married: 33.4% 8. Tampa, FL Photo Credit: Kevin J King / Shutterstock Percentage of adults currently divorced: 13.5% Percentage of adults currently separated: 2.4% Percentage of adults currently married: 38.5% Percentage of adults never married: 40.5% 7. Cleveland, OH Photo Credit: Sean Pavone / Shutterstock Percentage of adults currently divorced: 13.5% Percentage of adults currently separated: 3.4% Percentage of adults currently married: 24.7% Percentage of adults never married: 52.3% 6. Miami, FL Photo Credit: Galina Savina / Shutterstock Percentage of adults currently divorced: 13.5% Percentage of adults currently separated: 3.5% Percentage of adults currently married: 36.8% Percentage of adults never married: 39.8% 5. Las Vegas, NV Photo Credit: f11photo / Shutterstock Percentage of adults currently divorced: 13.8% Percentage of adults currently separated: 2.0% Percentage of adults currently married: 43.8% Percentage of adults never married: 35.3% 4. Jacksonville, FL Photo Credit: CHARLES MORRA / Shutterstock Percentage of adults currently divorced: 14.0% Percentage of adults currently separated: 2.2% Percentage of adults currently married: 42.3% Percentage of adults never married: 35.8% 3. Tucson, AZ Photo Credit: LHBLLC / Shutterstock Percentage of adults currently divorced: 14.3% Percentage of adults currently separated: 2.3% Percentage of adults currently married: 35.7% Percentage of adults never married: 42.5% 2. Tulsa, OK Photo Credit: Valiik30 / Shutterstock Percentage of adults currently divorced: 14.6% Percentage of adults currently separated: 2.5% Percentage of adults currently married: 42.2% Percentage of adults never married: 34.7% 1. Albuquerque, NM Photo Credit: turtix / Shutterstock Percentage of adults currently divorced: 15.1% Percentage of adults currently separated: 1.4% Percentage of adults currently married: 39.8% Percentage of adults never married: 38.2% Stay up-to-date on the latest in local and national government and political topics with our newsletter.
Dredging OK’d for Carlsbad lagoon will add sand to nearby beachesEDITOR'S NOTE: On Football analyzes the biggest topics in the NFL from week to week. No one wants to see any player take a vicious hit like the one that knocked Trevor Lawrence out of the game. It’s easy to agree on that point. Eliminating violent shots is the hard part. The NFL has instituted several rules to protect quarterbacks but football is a physical sport and players have to react instantly and make split-second decisions going at high speeds so injuries keep occurring. Lawrence was carted off the field in the first half of Jacksonville’s 23-20 loss to Houston on Sunday after Azeez Al-Shaair leveled the defenseless quarterback with a forearm to the facemask. The late hit put Lawrence in the fencing position — both fists clenched — and he stayed on the ground for several minutes, while a brawl ensued. Lawrence didn’t require hospitalization for his concussion but it’s unknown when he’ll return. “Thank you to everyone who has reached out/been praying for me,” Lawrence wrote on X. “I’m home and feeling better. Means a lot, thank you all.” Al-Shaair was ejected from the game and faces a fine and potential suspension after his latest unsportsmanlike penalty. The Texans' linebacker was flagged and later fined $11,255 for a late hit out of bounds on Titans running back Tony Pollard last week. He was fined earlier this year after he punched Bears running back Roschon Johnson on the sideline in Week 2. That occurred during a scuffle that started after his hard shot on quarterback Caleb Williams near the sideline that wasn’t flagged. Jacksonville Jaguars quarterback Trevor Lawrence slides in front of Houston Texans linebacker Azeez Al-Shaair during the first half of a game on Sunday in Jacksonville, Fla. Lawrence was injured on the play. Al-Shaair once got away with grabbing Tom Brady by the throat on a pass rush in a game between the 49ers and Buccaneers. Outraged Jaguars players called Al-Shaair’s hit “dirty” and Texans coach DeMeco Ryans made it known he didn’t condone it. “It’s not what we’re coaching,” Ryans said. “Want to be smart in everything we do and not hurt the team, get a penalty there. Have to be smarter when the quarterback is going down. Unfortunate play. Not representative of who Azeez is. He’s a smart player, really great leader for us. We felt his presence not being there. His loss really affected us on the defensive side. Just not what we’re coaching. Didn’t want to see the melee and all the aftermath. That’s not what we’re about. Not representative of us. I’ll talk to Azeez, address him personally, and we’ll move forward from it.” Fox Sports color analyst Daryl Johnston, a former fullback for the Dallas Cowboys, didn’t hold back his criticism, calling it a “cheap shot.” “It’s everything you’re not supposed to do,” Johnston said. “Everything. You’ll see this in slow motion and Azeez Al-Shaair does everything you’re trying to prevent in this situation. It’s reckless. It’s disrespectful. There’s an honor that you give to your opponent on the football field and you respect him. And there’s opportunities to be physical and give big hits and play this game in that manner. And there’s other times when there’s a respect that you grant to your opponent.” Some former NFL quarterbacks blasted Al-Shaair on social media. “There is no place in the game of football for dirty hits like this one,” Robert Griffin III wrote on X. Chase Daniel called it “one of the dirtiest hits” he’s ever seen on a quarterback. Jacksonville Jaguars tight end Evan Engram, right, jumps on Houston Texans linebacker Azeez Al-Shaair after his late hit on quarterback Trevor Lawrence, bottom, during the first half of a game on Sunday in Jacksonville, Fla. Even defensive players struggled to defend Al-Shaair. “That was uncalled for,” Hall of Fame defensive lineman Michael Strahan said on Fox’s studio show while fellow Hall of Famer Howie Long agreed. But the play also sparked debate about the quarterback slide. Lawrence slid feet first, which signals that he’s giving himself up on the play. The NFL rulebook states: “A defender must pull up when a runner begins a feet-first slide.” But defensive players aren’t automatically penalized if they make contact with a sliding quarterback if they already committed and the contact is unavoidable. The rules state it’s a foul when “the defender makes forcible contact into the head or neck area of the runner with the helmet, shoulder, or forearm, or commits some other act that is unnecessary roughness.” Al-Shaair did that so he was penalized and will face other repercussions. Still, given the hard-hitting nature of the sport, it won’t be the last time this happens. When Caleb Williams took the field for the Chicago Bears' first regular season game against the Tennessee Titans, the anticipation for the rookie's debut game—possibly the most ever—was on full display. Despite a tough debut for the quarterback, the Bears secured a 24-17 win, a notable feat for the rookie. The victory made Williams the first #1 overall pick with a Week 1 win in over 20 years. Going forward this season, Williams is expected to eclipse C.J. Stroud's record-breaking 2023 rookie campaign with the Houston Texans. However, Stroud's success is an anomaly. Drafting a successful quarterback, especially one who is effective right away, is difficult. When teams have a high first-round draft pick, and they're coming off an unsuccessful few seasons, it's assumed that they will use their first pick on a quarterback . That player will assume the title of "the face of the franchise" and will get the central attention, win or lose. To see which quarterbacks have faced that challenge and triumphed, ATS.io compiled a ranking of the 10 best rookie quarterbacks since 1960 using data from StatHead . Rookies were defined as players who are in their first season of professional football and have not been on the roster of another professional team. Quarterbacks were ranked according to adjusted net yards per pass attempt, which quantifies efficient passing skill. Ties were broken using passer rating. Only rookie quarterbacks with at least 10 games played and 200 total passing attempts were considered. Since 1967, 130 quarterbacks have been drafted in the first round. Of those drafted, only 61 have won a playoff game as a starter, according to The Athletic, which used data from NFL Research . The biggest reason this success rate is not guaranteed is because there are differences between college and pro offensive systems. In the collegiate game, the ball is snapped at different points on the field, passing windows are wider, and defenders and linemen are not as quick, making the adjustment to the pro level more difficult. NFL scouts and general managers are gambling on what skills can be transferable and how long those adjustments might take, which is why some teams prefer redshirt quarterbacks to ease the transition. However, just because a team may not want to use their first-round pick on a quarterback, doesn't mean they can't find a diamond in the rough later in the draft. Think about Tom Brady, Russell Wilson, and Dak Prescott, all of which were not first-round picks, but have gone on to make a name for themselves in the NFL. - Adjusted net yards per pass attempt: 6.44 - Passer rating: 91.2 - Season stats: 3,271 yards, 21 touchdowns, 6 interceptions Coming out of college, Gardner Minshew was not a highly sought-after quarterback for NFL teams. He was drafted in the sixth round of the 2019 draft—a draft that was headlined by Kyler Murray, Dwayne Haskins, and Daniel Jones. Nonetheless, Minshew's rookie season with the Jacksonville Jaguars was filled with many accomplishments. He won Rookie of the Week seven times despite not winning NFL Offensive Rookie of the Year. Minshew also had the highest passer rating of any rookie quarterback that started in 2019. - Adjusted net yards per pass attempt: 6.77 - Passer rating: 93.7 - Season stats: 3,725 yards, 27 touchdowns, 14 interceptions Pressure was high for Baker Mayfield as the first overall pick in the 2018 draft. When he joined the Cleveland Browns, there was an expectation that once the team figured out the quarterback position, it could be playoff-ready. After trading for Jarvis Landry, a young wide receiver from the Miami Dolphins, in the offseason, the Browns were on their way. Mayfield's rookie season was filled with many firsts, and the Landry-Mayfield connection filled the stat sheet. Mayfield set the record for most passing touchdowns by a rookie quarterback in 2019 with 27 surpassing prior marks from Payton Manning and Russell Wilson. - Adjusted net yards per pass attempt: 6.84 - Passer rating: 98.3 - Season stats: 4,336 yards, 31 touchdowns, 10 interceptions Justin Herbert was the third quarterback selected in the 2020 NFL draft behind Joe Burrow and Tua Tagovailoa. As the No. 6 overall pick, expectations were high, but there was also an assumption that it would be a few years before Herbert's development would take shape. Then, Chargers starting quarterback Tyrod Taylor was accidentally punctured in the lung by a team doctor administering a painkiller before the second game of the season, and it wasn't clear what Taylor's status would be moving forward. When Herbert was given the nod to start minutes before the game, fans didn't know what to expect. Herbert shocked viewers when he threw for over 300 yards and only one interception in that game. He continued his strong rookie showing throughout the season and went on to win NFL Offensive Rookie of the Year. - Adjusted net yards per pass attempt: 6.93 - Passer rating: 98.1 - Season stats: 2,621 yards, 17 touchdowns, 11 interceptions Ben Roethlisberger was the third quarterback selected in his draft class behind the likes of Eli Manning and Philip Rivers—though fans wouldn't have been able to tell. From the moment Roethlisberger was called up by the Pittsburgh Steelers to play in his first game—Week 2 against the Baltimore Ravens—it was clear he had a special arm, gaining the nickname "Golden Arm." While the next several games were bumpy for Steelers fans, it was clear that Roethlisberger was the future of the franchise. The Steelers had a solid running game and its receiving core, led by Hines Ward, was one of the best in the league . Once Roethlisberger gained his footing a few games in, he was unstoppable. He led Pittsburgh to its best record ever: 15-1. He also started the season on an eight-game winning streak, becoming the first rookie to do so. Additionally, Roethlisberger became the first quarterback to win AP Offensive Rookie of the Year. - Adjusted net yards per pass attempt: 7.01 - Passer rating: 87.7 - Season stats: 3,440 yards, 16 touchdowns, 11 interceptions As the No. 3 overall pick in the 2008 NFL draft, there were high expectations on Matt Ryan's shoulders heading to the Atlanta Falcons. The Falcons were coming off back-to-back losing seasons and off-the-field legal troubles with its starting quarterback Michael Vick overshadowing the team's play. Ryan was expected to pick up the pieces. He did that immediately, leading the Falcons to an 11-5 record in his rookie season and becoming the clear favorite for NFL Offensive Rookie of the Year halfway through the season, which he went on to win. The tag team of Ryan and running back Michael Turner was one of the best offensive forces in the sport that season. - Adjusted net yards per pass attempt: 7.01 - Passer rating: 100 - Season stats: 3,118 yards, 26 touchdowns, 10 interceptions Russell Wilson was drafted in the third round of the 2012 NFL Draft by the Seattle Seahawks. Considering Robert Griffin III and Andrew Luck headlined the NFL Draft that year, it was not believed that Wilson would be a starter come Week 1, but that quickly changed. Going into the 2012 NFL Draft, Tarvaris Jackson was the Seattle Seahawks' starting quarterback, and the team signed NFL veteran quarterback Matt Flynn as an insurance policy on the injury-prone Jackson . It was assumed in the short term that either Jackson or Flynn would lead the franchise. Once training camp arrived, however, the Seahawks' quarterback position was uncertain. Jackson was traded to the Buffalo Bills, and Flynn was underwhelming at camp, forcing Head Coach Pete Carroll to take a gamble on his rookie quarterback, Wilson, in Week 1. Carroll, nor Wilson, ever looked back. Wilson was one of the best passing quarterbacks that season. He led the Seahawks to an 11-5 record and went on to win NFL Rookie of the Year. - Adjusted net yards per pass attempt: 7.47 - Passer rating: 100.8 - Season stats: 4,108 yards, 23 touchdowns, 5 interceptions When C.J. Stroud was drafted No. 2 by the Houston Texans last year, there were a lot of questions, not about his ability, but about the organization that he would be playing for. The Texans were coming off of a 3-13-1 season in 2022, finishing with the worst record in the league, and a lot of volatility in its front office. The team fired its head coach and a top executive before the draft. Weeks later, the team hired former Texans linebacker DeMeco Ryans as its next head coach. While Ryans is a defensive-minded coach, Stroud was seen as a key ingredient to the team's success since Ryans hired his coaching staff around the quarterback. Stroud led the NFL in yards and TD-to-interception ratio during his rookie season, which is an efficiency statistic considering he didn't get his first interception until his sixth regular-season game against the New Orleans Saints. While Stroud was a part of the league MVP conversation for most of the season, he didn't ultimately win the title. However, he was named 2023 NFL Offensive Rookie of the Year, and his rookie season is seen as one of the best in NFL history. - Adjusted net yards per pass attempt: 7.47 - Passer rating: 102.4 - Season stats: 3,200 yards, 20 touchdowns, 5 interceptions Leading into the 2012 draft, it wasn't a matter of whether Washington would pick a quarterback, it was a matter of who. After several seasons of mediocre quarterback play and losing seasons from the likes of Jason Campbell, Donovan McNabb, and Rex Grossman, it was time for a new face to lead the offense. At No. 2, Washington selected Robert Griffin III making him the second quarterback selected in the 2012 NFL draft behind Andrew Luck. Griffin started his rookie year campaign with one of the best performances football fans have ever seen. He completed 19 of his 26 pass attempts for 320 yards and 2 touchdowns, beating the New Orleans Saints. That game earned him the highest passer rating by a rookie ever, 158.3. He now shares that record with Kirk Cousins and Marcus Mariota. Griffin III went on to win NFL Offensive Rookie of the Year in 2012. - Adjusted net yards per pass attempt: 7.86 - Passer rating: 104.9 - Season stats: 3,667 yards, 23 touchdowns, 4 interceptions Dak Prescott is statistically the best rookie quarterback ever, racking up the best passer rating as a rookie. After losing his first game, he led the Cowboys on an 11-game winning streak. That season, he led the team to its fourth-best season ever with a 13-3 record. Prescott was the 2016 NFL Offensive Rookie of the Year and became the first NFL quarterback to be drafted in the fourth round or later to start all 16 regular season games. Data reporting by Karim Noorani. Story editing by Shanna Kelly. Additional editing by Kelly Glass. Copy editing by Robert Wickwire. Photo selection by Clarese Moller. This story originally appeared on ATS.io and was produced and distributed in partnership with Stacker Studio. Get local news delivered to your inbox!Published 4:19 pm Thursday, November 21, 2024 By Staff Reports Friday’s college basketball slate includes four games featuring a ranked team in action. Among those contests is the Oklahoma Sooners taking on the UNLV Rebels. Watch women’s college basketball, other live sports and more on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Use our link to sign up for a free trial. Catch tons of live women’s college basketball , plus original programming, with ESPN+ or the Disney Bundle.