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card game baccarat GCC-4001 is under clinical development by Artiva Biotherapeutics and currently in Phase II for Waldenstrom Macroglobulinemia (Lymphoplasmacytic Lymphoma). According to GlobalData, Phase II drugs for Waldenstrom Macroglobulinemia (Lymphoplasmacytic Lymphoma) have a 26% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. GCC-4001 overview GCC-4001 (AB-101) is under development for the treatment of rheumatoid arthritis, systemic lupus erythematosus, pemphigus vulgaris, granulomatosis with polyangiitis and microscopic polyangiitis, B-cell non-Hodgkin lymphoma, relapsed or refractory chronic lymphocytic leukemia, diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, follicular lymphoma, Waldenstrom Macroglobulinemia, peripheral T-cell lymphomas (PTCL), angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma (ALCL), R/R classical Hodgkin lymphoma, lupus nephritis (LN) and autoimmune disorders. The therapeutic candidate is an allogeneic, non-engineered, cord blood-derived natural killer (NK) cell therapy. It is administered through intravenous route and is being developed based on AlloNK platform. Artiva Biotherapeutics overview Artiva Biotherapeutics is a biotechnology company developing allogeneic natural killer (NK) cell therapies to treat hematologic cancers or solid tumors. It is investigating AB-101, an allogeneic NK cell therapy used for the treatment of B-cell malignancies; AB-201, a CAR-NK (chimeric antigen receptor-modified natural killer) cell therapy targeting HER2 positive solid tumors; and AB-202 against CD19 positive B-cell malignancies. Artiva Biotherapeutics utilizes its proprietary CAR (chimeric antigen receptor) platform to improve NK cells’ therapeutic activity and tumor-targeting capability. Artiva Biotherapeutics is headquartered in San Diego, California, the US. For a complete picture of GCC-4001’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .

COPPER MOUNTAIN, Colo. — For a pair of lower-level downhill events, this sure had plenty of Olympic medal-capturing and World Cup-winning ski racers. The stage belonged to Lindsey Vonn, the 40-year-old who took another step on her comeback trail Saturday with her first races in nearly six years. Vonn wasn't particularly speedy and finished in the middle of the pack on a cold but sunny day at Copper Mountain. Times and places weren't the mission, though, as much as getting used to the speed again and gaining the necessary points to compete on the World Cup circuit this season. Vonn accomplished both, finishing 24th in the first downhill race of the day and 27th in the second. She posted on social media after the FIS races that she had enough points to enter World Cup events. The timing couldn't be more perfect — the next stop on the women's circuit is Beaver Creek, Colorado, in a week. Vonn, who used to own a home in nearby Vail, hasn't committed to any sort of timetable for a World Cup return. “Today was a solid start and I had a blast being in start with my teammates again!” Vonn wrote on X. “While I’m sure people will speculate and say I’m not in top form because of the results, I disagree. This was training for me. I’m still testing equipment and getting back in the groove.” Lindsey Vonn reacts after her run at a downhill skiing race at Copper Mountain Ski Resort on Saturday in Copper Mountain, Colo. Her competition — a veritable who's who of high-profile ski racers — applauded her efforts. “I don't expect her to come back and win — just that she comes back and she has fun,” said Federica Brignone of Italy, a former overall World Cup champion and three-time Olympic medalist. “She's having fun, and she’s doing what she loves. That’s the best thing that she could do.” In the first race on a frigid morning, Vonn wound up 1.44 seconds behind the winning time of 1 minute, 5.79 seconds posted by Mirjam Puchner of Austria. In her second race through the course later in the morning, Vonn was 1.53 seconds behind Cornelia Huetter of Austria, who finished in 1:05.99. Huetter is the reigning season-long World Cup downhill champion. “It’s really nice to compare with her again, and nice to have her (racing) again,” Huetter said. “For sure, for the skiing World Cup, we have a lot of more attention. It's generally good for all racers because everyone is looking.” Also in the field were Nadia Delago of Italy, who won a bronze medal in downhill at the 2022 Beijing Olympics, and Puchner, the Olympic silver winner in super-G in Beijing. In addition, there was Marta Bassino of Italy, a winner of the super-G at the 2023 world championships, and two-time Olympic champion Michelle Gisin of Switzerland. “For me, it was really a training, but it was fun to have a World Cup race level right here,” Gisin said. “It was a crazy race.” Vonn remains a popular figure and took the time after each run to sign autographs for young fans along with posing for photos. When she left the sport, Vonn had 82 World Cup race victories, which stood as the record for a woman and within reach of the all-time Alpine record of 86 held by Swedish standout Ingemar Stenmark. The women’s mark held by Vonn was surpassed in January 2023 by Mikaela Shiffrin, who now has 99 wins — more than any Alpine ski racer in the history of the sport. Shiffrin is currently sidelined after a crash in a giant slalom event in Killington, Vermont, last weekend. Vonn’s last major race was in February 2019, when she finished third in a downhill during the world championships in Sweden. The three-time Olympic medalist left the circuit still near the top of her game. But all the broken arms and legs, concussions and torn knee ligaments took too big a toll and sent her into retirement. She had a partial knee replacement last April and felt good enough to give racing another shot. “It's very impressive to see all the passion that Lindsey still has,” Gisin said. Also racing Saturday was 45-year-old Sarah Schleper, who once competed for the United States but now represents Mexico. Schleper was the next racer behind Vonn and they got a chance to share a moment between a pair of 40-somethings still racing. “I was like, ‘Give me some tips, Lindsey,’” Schleper said. “She’s like, ‘Oh, it’s a highway tuck, the whole thing.’ Then she’s like, ‘It’s just like the good old days.’" Buffalo Bills quarterback Josh Allen, foreground right, dives toward the end zone to score past San Francisco 49ers defensive end Robert Beal Jr. (51) and linebacker Dee Winters during the second half of an NFL football game in Orchard Park, N.Y., Sunday, Dec. 1, 2024. (AP Photo/Adrian Kraus) Houston Rockets guard Jalen Green goes up for a dunk during the second half of an Emirates NBA cup basketball game against the Minnesota Timberwolves, Tuesday, Nov. 26, 2024, in Minneapolis. 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(AP Photo/Lindsey Wasson) New York Islanders left wing Anders Lee (27), center, fight for the puck with Boston Bruins defensemen Parker Wotherspoon (29), left, and Brandon Carlo (25), right during the second period of an NHL hockey game, Wednesday, Nov. 27, 2024, in Elmont, N.Y. (AP Photo/Julia Demaree Nikhinson) Jiyai Shin of Korea watches her shot on the 10th hole during the final round of the Australian Open golf championship at the Kingston Heath Golf Club in Melbourne, Australia, Sunday, Dec. 1, 2024. (AP Photo/Asanka Brendon Ratnayake) Lara Gut-Behrami, of Switzerland, competes during a women's World Cup giant slalom skiing race, Saturday, Nov. 30, 2024, in Killington, Vt. (AP Photo/Robert F. Bukaty) New York Islanders goaltender Ilya Sorokin cools off during first period of an NHL hockey game against the Boston Bruins, Wednesday, Nov. 27, 2024, in Elmont, N.Y. (AP Photo/Julia Demaree Nikhinson) Brazil's Amanda Gutierres, second right, is congratulated by teammate Yasmin, right, after scoring her team's first goal during a soccer international between Brazil and Australia in Brisbane, Australia, Thursday, Nov. 28, 2024. (AP Photo/Pat Hoelscher) Las Vegas Raiders tight end Brock Bowers (89) tries to leap over Kansas City Chiefs cornerback Joshua Williams (2) during the first half of an NFL football game in Kansas City, Mo., Friday, Nov. 29, 2024. (AP Photo/Ed Zurga) Gold medalists Team Netherlands competes in the Team Sprint Women race of the ISU World Cup Speed Skating Beijing 2024 held at the National Speed Skating Oval in Beijing, Sunday, Dec. 1, 2024. (AP Photo/Ng Han Guan) Minnesota Vikings running back Aaron Jones (33) reaches for an incomplete pass ahead of Arizona Cardinals linebacker Mack Wilson Sr. (2) during the second half of an NFL football game Sunday, Dec. 1, 2024, in Minneapolis. (AP Photo/Abbie Parr) Melanie Meillard, center, of Switzerland, competes during the second run in a women's World Cup slalom skiing race, Sunday, Dec. 1, 2024, in Killington, Vt. (AP Photo/Robert F. Bukaty) South Carolina guard Maddy McDaniel (1) drives to the basket against UCLA forward Janiah Barker (0) and center Lauren Betts (51) during the first half of an NCAA college basketball game, Sunday, Nov. 24, 2024, in Los Angeles. (AP Photo/Eric Thayer) Philadelphia Eagles running back Saquon Barkley, left, is hit by Baltimore Ravens cornerback Marlon Humphrey, center, as Eagles wide receiver Parris Campbell (80) looks on during a touchdown run by Barkley in the second half of an NFL football game, Sunday, Dec. 1, 2024, in Baltimore. (AP Photo/Stephanie Scarbrough) Mathilde Gremaud of Switzerland competes in the women's Freeski Big Air qualifying round during the FIS Snowboard & Freeski World Cup 2024 at the Shougang Park in Beijing, Friday, Nov. 29, 2024. (AP Photo/Andy Wong) Luiz Henrique of Brazil's Botafogo, right. is fouled by goalkeeper Everson of Brazil's Atletico Mineiro inside the penalty area during a Copa Libertadores final soccer match at Monumental stadium in Buenos Aires, Argentina, Saturday, Nov. 30, 2024. (AP Photo/Natacha Pisarenko) England's Alessia Russo, left, and United States' Naomi Girma challenge for the ball during the International friendly women soccer match between England and United States at Wembley stadium in London, Saturday, Nov. 30, 2024. (AP Photo/Kirsty Wigglesworth) Get local news delivered to your inbox!

By MARC LEVY HARRISBURG, Pa. (AP) — Democratic Sen. Bob Casey of Pennsylvania conceded his reelection bid to Republican David McCormick on Thursday, as a statewide recount showed no signs of closing the gap and his campaign suffered repeated blows in court in its effort to get potentially favorable ballots counted. Casey’s concession comes more than two weeks after Election Day, as a grindingly slow ballot-counting process became a spectacle of hours-long election board meetings, social media outrage, lawsuits and accusations that some county officials were openly flouting the law. Republicans had been claiming that Democrats were trying to steal McCormick’s seat by counting “illegal votes.” Casey’s campaign had accused of Republicans of trying to block enough votes to prevent him from pulling ahead and winning. In a statement, Casey said he had just called McCormick to congratulate him. “As the first count of ballots is completed, Pennsylvanians can move forward with the knowledge that their voices were heard, whether their vote was the first to be counted or the last,” Casey said. The Associated Press called the race for McCormick on Nov. 7, concluding that not enough ballots remained to be counted in areas Casey was winning for him to take the lead. As of Thursday, McCormick led by about 16,000 votes out of almost 7 million ballots counted. That was well within the 0.5% margin threshold to trigger an automatic statewide recount under Pennsylvania law. But no election official expected a recount to change more than a couple hundred votes or so, and Pennsylvania’s highest court dealt him a blow when it refused entreaties to allow counties to count mail-in ballots that lacked a correct handwritten date on the return envelope. Republicans will have a 53-47 majority next year in the U.S. Senate. Follow Marc Levy at twitter.com/timelywriter Click to share on Facebook (Opens in new window) Click to share on X (Opens in new window) Most Popular Court documents: 3-year-old grabbed dad’s gun off kitchen counter and accidentally shot himself Court documents: 3-year-old grabbed dad’s gun off kitchen counter and accidentally shot himself Virginia Beach man accused of striking state trooper with car after pursuit Virginia Beach man accused of striking state trooper with car after pursuit Entertainment venue Uptown Alley no longer coming to Williamsburg Entertainment venue Uptown Alley no longer coming to Williamsburg Trump chooses Pam Bondi for attorney general pick after Gaetz withdraws Trump chooses Pam Bondi for attorney general pick after Gaetz withdraws Ex-student pleads guilty to fatally shooting 3 University of Virginia football players in 2022 Ex-student pleads guilty to fatally shooting 3 University of Virginia football players in 2022 Virginia’s withdrawal from RGGI was ‘unlawful,’ judge rules Virginia’s withdrawal from RGGI was ‘unlawful,’ judge rules Man tried to rob Virginia Beach 7-Eleven with knife, officials say, before police shot him Man tried to rob Virginia Beach 7-Eleven with knife, officials say, before police shot him 2 school buses involved in crash in James City County. Here’s what happened. 2 school buses involved in crash in James City County. Here's what happened. Newport News’ first Saladworks combines former doctor’s passions for health and business Newport News’ first Saladworks combines former doctor’s passions for health and business Meet the Fort Monroe Authority’s new CEO Meet the Fort Monroe Authority’s new CEO Trending Nationally ‘End of an era’: What’s next for Matt Gaetz? When ‘compostables’ are actually garbage School bus driver accused of abandoning 40 elementary students miles from home More foods are making us sick: What to know as foodborne outbreaks hit consumers San Diego toddler’s backyard snake bite bills totaled more than a quarter-million dollars

The Giants were embarrassed in Sunday's 30-7 loss , taunted by Mayfield after a touchdown run just before halftime. And then they saw their fans walk out on them again when the Bucs extended their lead to 30-0 and sent New York (2-9) to its sixth straight loss. The losing streak is the longest for the Giants since 2019, when they dropped a franchise-record nine straight games to finish 4-12. That led to the firing of coach Pat Shurmur after two seasons. Third-year coach Brian Daboll is clearly in trouble, with the Giants guaranteed a second straight losing season. They were 6-11 in a 2023 season that featured a lot of injuries. Daboll, who denies he has lost the team, isn't the only one whose job is in jeopardy. General manager Joe Schoen is on the hot seat and so is this entire franchise, which is celebrating its 100th year. It's one thing to lose. It's quite another to give up, and that's what the organization did when it decided to bench Daniel Jones a week ago and then release him on Friday after the 27-year-old asked co-owner John Mara to let him walk away. While he wasn't playing well, Jones was the Giants' best quarterback. He gave them more a of chance to win than either Tommy DeVito or Drew Lock. Removing him from the picture was all but certain to make the Giants worse, even if it was a good business decision. If Jones was hurt and unable the pass his physical before the 2025 season, the team would have been on the hook for a $23 million cap hit. The problem is the players care about now. By getting rid of Jones and elevating DeVito to the starting role, the front office was telling the team it didn't care about winning with seven games left in the season. So the players gave a lackluster effort. Defensive tackle Dexter Lawrence called the team soft. Rookie receiver Malik Nabers said he was sick of losing. Left tackle Jermaine Eluemunor said he saw a lack of effort by some players. What they all were saying was they were angry at being betrayed. Money is never more important than winning, and the Giants made that mistake. At this point in the season? Nothing. The offense once again. The Giants have scored a league-low 163 points, including only 60 in six games at MetLife Stadium, where they are winless this season. They have scored in double figures at home twice. Daboll's team has been held scoreless in the first half in three of 11 games and it has been held without a first-half touchdown seven times. Daboll said he will continue to call the offensive plays. S Tyler Nubin. The rookie has had a team-high 12 tackles in each of the last two games. His 81 tackles for the season are just two behind team leader Bobby Okereke. RB Tyrone Tracy. The rookie leads Giants running backs with 587 yards on 116 carries — a 5.1-yard average for the fifth-round pick. But holding onto the ball has been a big issue. Tracy's fumble in overtime cost New York a chance to win in Germany against Carolina. He also lost the ball in the third quarter at the Bucs 5-yard line with New York down 23-0. It earned him a seat on the bench. LT Jermaine Eluemunor (quad) and OLB Azeez Ojulari (toe) left Sunday's game in the first quarter. Chris Hubbard filled in at tackle and the Giants luckily got back DL Kayvon Thibodeaux this past week after he missed five games with a broken wrist. DeVito was banged up but Daboll expects him to start against the Cowboys. 10 — The Giants have gone 10 consecutive games without an interception, tying the NFL record held by the 1976-77 San Francisco 49ers and the 2017 Oakland — now Las Vegas — Raiders. The Giants and Raiders now share the single-season mark. A national showcase on Thanksgiving Day for the NFC-worst Giants at Dallas. AP NFL: https://apnews.com/hub/NFLDoha: The State of Qatar, represented by the Ministry of Municipality, is celebrating World Soil Day, which falls on December 5 each year. Held under the theme of rural soil care: measurement, monitoring, and management, the celebration intends to shine a spotlight on the importance of accurate data and information to figure out soil characteristics, as well as support insightful decisions on the sustainable management of soil, thereby fostering food security. The State of Qatar's participation in marking this day stems from the Qatar National Vision 2030, that seeks to achieve sustainable development, including the preservation of environment and natural resources, as long as the priority given to soil is a core part of environment protection, in addition to achieving sustainability in utilizing natural resources and reducing desertification. In addition, the Ministry of Municipality, represented by the Department of Agricultural Research, has accomplished concrete results in protecting soil and lands in Qatar from wind-induced degeneration, erosion and desertification through protecting the plant genetic resources and biodiversity, as well as the national Gene Bank. Director of the Agricultural Research Department at the Ministry of Municipality, Hamad Saket Al Shammari, stated that the Qatari genetic seed bank currently includes 1,138 plant entries, comprising many local wild plants such as Al Ghaf Sidr, Awsaj and others, as well as plants related to food and agriculture, such as tomatoes, corn, onions, et al. He highlighted that the key objective of this bank is to preserve seeds that are compatible with the soil and climate conditions in Qatar after conducting the necessary research on them. Additionally, the Department of Agricultural Research is making significant efforts in scientific research and development to optimize soil quality and increase its productivity, while leveraging various technologies, especially in light of the focus on achieving and sustaining food security, added Al Shammari. He highlighted several critical successes that have been made to protect biodiversity and soil in Qatar, in collaboration with the Ministry of Environment and Climate Change, since 2015, such as the protection of the Qatari Al Ghaf at Al Ghaf meadow in the north of Qatar, where an overall research was conducted on the site to receive the essential imprimaturs to embark on implementing an integrated plan that included fencing the area and cleaning it from harmful and invasive plants, primarily the Mesquite plant, in addition to exploring the most appropriate scientific techniques to propagate Al Ghaf seeds and recultivate its offshoots These efforts resulted in restoring the site's standard environmental criteria, where the vegetation cover density and soil coverage with plants and plant remains have increased in the summer, and subsequently the wild Al Ghaf trees have developed, with an increase in their annual seed production, after they were in a state of severe degeneration prior to taking the protection decision, Al Shammari outlined. Aisha Dasmal Al Kuwari from the Department of Agricultural Research asserted that since its inception in 2012, the Qatar Gene Bank has succeeded in studying and collating approximately 70% of local plant species in a form of seeds, along with herbaceous plants and DNA samples, emphasizing that plant genetic resources are one of the national assets with strategic and economic value, since directly or indirectly support human livelihoods and ensure stability by providing food, medicine, fodder, fibers, clothing, shelter, and energy, in addition to their crucial role in conserving the environment and preventing soil degradation and erosion. The Gene Bank pursues a sophisticated system to manage and document genetic resources in compliance with international standards, with overall data for each type logged in the international database of Qatar's Gene Bank. This database was established in 2015, in collaboration with the Arab Organization for Agricultural Development (AOAD), highlighted Al Kuwari. For his part, Biotechnology & Genetic Resources Expert at Ministry of Municipality, Dr. Elsayed M. Elazazi, indicated that the Qatari Gene Bank compiled 1,138 samples from various sites across the State of Qatar that included over 9 million seeds saved under standard conditions, either for long or short term preservation mechanism, representing over 150 species and nearly 200 unique species, with a special focus on vital domestic types that prevent land degeneration and enhance their sustainable management. Noteworthy, the State of Qatar has successfully activated the law of the unified system for the management of plant genetic resources proposed by Qatar for the Gulf Cooperation Council (GCC) states to protect the rights of GCC states over their local plants and regulate the mechanism for sharing genetic resources among the countries.